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目的 考察香荷药条在体内外释药的相关性。方法 体外溶出方法采用电磁搅拌法 ,体内释药量采用测定给药系统体内释药后剩余药量的方法间接测定 ,采用 HPL C法以盐酸小檗碱的含量变化作为考察指标。结果 香荷药条的体内释药百分率与体外释放百分率之间存在良好的相关性。结论 香荷药条可通过控制其体外释放达到预测体内吸收的目的。
Objective To investigate the relativity of the release of Xianghe bar in vitro and in vivo. Methods In vitro dissolution method using electromagnetic stirring method, in vivo drug release determination of drug delivery system in vivo drug release method of indirect determination of the use of HPL C method to berberine hydrochloride content changes as an inspection index. Results There was a good correlation between the percentage of in vivo drug release and the percentage of in vitro release of Xianghe bar. Conclusion The stalks can be controlled to release in vitro to predict the absorption in vivo.