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本文采用细胞核仁组成区嗜银蛋白技术观察了人乳头瘤病毒（ＨＰＶ）感染阳性食管癌蜡块切片２Ｏ例，阴性组１４例。结果发现ＨＰＶ感染阳性癌肿细胞核仁组成区嗜银蛋白计数（１１．３５６±１．６２８，－ｘ±ｓ）明显高于阴性组（５．３３９±０．７９６，－ｘ±ｓ），两组差异显著（Ｐ＜０．０５）。该结果说明ＨＰＶ感染阳性的食管癌细胞的增殖较阴性活跃，ＨＰＶ感染性癌肿的恶性度较阴性高，预后差，对食管癌的临床治疗有一定的指导意义。
In this paper, nucleolar organizer region of argyrophilic protein technology was used to observe 2O cases of human papillomavirus (HPV) -positive esophageal cancer paraffin section and 14 cases of negative group. The results showed that the counts of argyrophilic proteins in nucleolar organizer regions of HPV-positive cancer cells (11.356 ± 1.628, -x ± s) were significantly higher than those in the negative group (5.339 ± 0.796, -x ± s) Group difference was significant (P <0.05). The results showed that HPV-positive esophageal cancer cells were more active than negative ones. The malignant degree of HPV-infected cancers was more negative and the prognosis was poor, which had some guiding significance for the clinical treatment of esophageal cancer.