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腹痛是功能性胃肠病(FGIDs),特别是肠易激综合征(IBS)的主要症状之一,严重影响患者的生活质量。然而,其病理生理学机制复杂且仍未明确。大麻素已被应用于疼痛机制的研究和临床治疗,但成瘾性等中枢系统不良反应限制了其应用。因此,研究大麻素系统的外周作用途径,对提高大麻素治疗慢性疼痛(特别是内脏痛)的效果,具有重要意义。本文就大麻素系统与胃肠道内脏痛调控关系的研究进展作一综述。
Abdominal pain is one of the major symptoms of functional gastrointestinal disorders (FGIDs), especially irritable bowel syndrome (IBS), and seriously affects the quality of life of patients. However, its pathophysiological mechanism is complex and still not clear. Cannabinoids have been used in research and clinical treatment of pain mechanisms, but central nervous system adverse effects such as addiction have limited their use. Therefore, studying the peripheral pathways of the cannabinoid system is of great importance to improve the efficacy of cannabinoids in the treatment of chronic pain (especially visceral pain). This article reviews the research progress of the relationship between cannabinoid system and gastrointestinal visceral pain.