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英国在西欧销售一种能抑制与关节炎相关的疼痛的药丸,名弗尔多因,有效成份是Piroxicam。口服一粒可止痛24小时,对骨关节炎、类风湿关节炎、关节强硬性关节炎,以及对粘液囊炎、腱炎和痛风的剧痛起有效的止痛作用。其在血中半生期为38小时,不在体内积蓄,很快达到有效血浓度。据研究该药有三个作用:①通过抑制环化加氧酶来抑制细胞内从花生四烯酸合成前列腺素E_2和凝血恶烷(这两种物质是参与造成与炎症相关的疼痛的物质)。②减少白细胞移行到关节间隙,使这些白细胞释放的炎症物质亦减少。③该药是通过
Britain sells a pill in Western Europe that inhibits arthritis-related pain, known as Verdorin, and the active ingredient is Piroxicam. Oral one can relieve pain for 24 hours, effective on osteoarthritis, rheumatoid arthritis, arthritis and arthritis, as well as bursitis on bursitis, tendonitis and gout pain effectively. Its half-life in the blood for 38 hours, not in the body savings, and soon to achieve effective blood concentration. It has been reported that the drug has three functions: (1) Inhibition of intracellular synthesis of prostaglandin E_2 and thromboxane from arachidonic acid (a substance involved in causing inflammation-related pain) by inhibiting cyclooxygenase. ② reduce leukocyte migration to the joint space, so that the white blood cells release of inflammatory substances are also reduced. ③ The drug is passed