内毒素或山莨菪碱单独使用均不引起磷脂酰胆碱—磷脂酸—胆固醇脂质体的聚集反应。但内毒素与脂质体预先孵化,明显促进Ca~(2+)引起的脂质体聚集反应,其效应呈剂量依赖关系。山莨菪碱与脂质体预先孵化,对Ca~(2+)引起的脂质体聚集反应无明显影响,但显著抑制内毒素对Ca~(2+)引起的脂质体聚集反应的促进作用。山莨菪碱对内毒素的抑制效应呈剂量依赖关系。 Neither endotoxin nor anisodamine alone caused the aggregation of phosphatidylcholine-phosphatidic acid-cholesterol liposomes. However, the preincubation of endotoxin with liposomes significantly promoted the aggregation of liposomes induced by Ca 2+, and the effect was dose-dependent. Preincubation of anisodamine with liposome had no significant effect on the aggregation of liposomes induced by Ca ~ (2+), but significantly inhibited the promotion of lipopolysaccharide - induced aggregation by endotoxin . Anisodamine inhibited the endotoxin in a dose-dependent manner.