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目的:观察复合维生素预防体外受精-胚胎移植(IVF-ET)胎儿神经管缺损的效果。方法:回顾性分析华中科技大学附属同济医院生殖中心2005年1月~2010年12月接受IVF-ET并妊娠患者4 195例,其中移植后未服用复合维生素患者1 502例(A组),移植后服用复合维生素患者2 693例(B组)。比较两组胎儿神经管缺损的发生率。结果:A组发生胎儿神经管缺损6例,神经管缺损发病率为4.00‰,B组未发生神经管缺损。两组神经管缺损发病率比较有统计学差异(P“,”Objective:To observe the preventive effect of multivitamin on fetal neural tube defect after in vitro fertilization-embryo transfer(IVF-ET).Methods:A total of 4 195 patients who received IVF-ET and got pregnancy in the hospital from January 2005 to December 2010 were analyzed retrospectively,and then they were divided into group A(including 1 502 patients not taking multivitamin after IVF-ET) and group B(including 2 693 patients taking multivitamin after IVF-ET).The incidence rates of neural tube defect in the two groups were compared.Results:The incidence rate of neural tube defect in group A was 4.00‰(6 fetuses),while in group B,no fetus was found with neural tube defect.There was statistically significant difference in the incidence rate of neural tube defect between the two groups(P<0.05).Conclusion:Multivitamin used after IVF-ET can prevent fetal neural tube defect.