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目的观察左氧氟沙星联合常规结核化疗方案治疗复治涂阳肺结核患者的临床疗效及安全性。方法将70例复治涂阳肺结核患者随机分为观察组和对照组,每组35例。观察组给予左氧氟沙星联合常规结核化疗方案治疗,对照组给予常规结核化疗方案治疗,比较2组临床治疗效果和不良反应发生率。结果观察组各时间段痰涂转阴率和总有效率均高于对照组,差异均有统计学意义(P<0.05或P<0.01)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论在抗结核化疗方案的基础上加用左氧氟沙星治疗复治涂阳肺结核患者可显著提高痰涂转阴率,且不增加不良反应,值得临床医师借鉴应用。
Objective To observe the clinical efficacy and safety of levofloxacin plus conventional tuberculosis chemotherapy in the treatment of patients with relapsed and smear-positive pulmonary tuberculosis. Methods Seventy patients with relapsed smear-positive pulmonary tuberculosis were randomly divided into observation group and control group, 35 cases in each group. The observation group was treated with levofloxacin in combination with conventional tuberculosis chemotherapy and the control group with conventional tuberculosis chemotherapy. The clinical effects and the incidence of adverse reactions were compared between the two groups. Results The sputum smear negative rate and total effective rate in the observation group were higher than those in the control group at each time point, the differences were statistically significant (P <0.05 or P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The addition of levofloxacin to patients with relapsed and smear-positive pulmonary tuberculosis based on the anti-tuberculosis chemotherapy regimen can significantly increase the negative rate of sputum smear without increasing adverse reactions, which is worth learning and application by clinicians.