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目的探讨炎性肌纤维母细胞肿瘤(IMT)的临床病理特点、诊断与鉴别诊断。方法对2例IMT的组织病理学、免疫组化结果进行观察分析,结合文献进行讨论。结果 IMT镜下主要由肌纤维母细胞、纤维母细胞和炎细胞组成,表现为黏液丰富区和富于细胞区,梭形和星芒状肿瘤细胞散在或束状排列,间质可见大量纤细扩张的小血管网形成。所有病例vimentin、SMA和Ig G(+),部分病例desmin和CD68(+)。2例目前均存活,1例复发。结论 IMT是一种较为罕见的间叶性肿瘤,主要依据其病理形态学特点并结合免疫表型进行诊断与鉴别诊断。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of inflammatory myofibroblastic tumor (IMT). Methods Two cases of IMT histopathology, immunohistochemistry results were observed and analyzed, combined with the literature to discuss. Results IMT mainly composed of myofibroblasts, fibroblasts and inflammatory cells showed mucus-rich area and rich in cell area, spindle-shaped and asteroid tumor cells scattered or bundles arranged in the stroma can be seen a large number of fine expansion Small blood vessel network formation. All cases were vimentin, SMA and Ig G (+), some cases were desmin and CD68 (+). Two patients survived at present and one patient relapsed. Conclusion IMT is a relatively rare mesenchymal tumor, which is mainly diagnosed and differentiated according to its pathomorphological features and immunophenotype.