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采用微量乙肝疫苗（总剂量为６μｇ）对ＨＢＶ高流行区居民进行随机对照研究，免疫Ⅰ组（疫苗＜８℃保存）Ｔ１２抗体阳转率和保护率分别为９０．８％和８７．０％，和对照组相比，差异显著（Ｐ均＜０．００１）；和常规剂量（总剂量９０μｇ）比，其抗体阳转率和保护率基本相同。提示ＨＢＶ高流行区可用微量乙肝苗代替常量乙肝苗进行预防接种。免疫Ⅰ组和免疫Ⅱ组（乙肝疫苗室温保藏２８℃±）免疫效果和保护率基本相同，认为室温条件下乙肝疫苗６个月内效价不变。
A small amount of hepatitis B vaccine (total dose of 6μg) for residents of high HBV prevalence randomized controlled study, immune group Ⅰ (vaccine <8 ℃ preservation) T12 antibody positive rate and protection rate were 90.8% and 87.0% (P <0.001). Compared with the control group, the antibody positive rate and the protection rate were basically the same as the conventional dose (total dose 90μg). Prompt HBV high prevalence area available trace hepatitis B vaccine instead of constant hepatitis B vaccination. Immune Ⅰ group and immune Ⅱ group (Hepatitis B vaccine stored at room temperature 28 ℃ ±) immune effect and the protection rate is basically the same, that the room temperature hepatitis B vaccine within 6 months the same price.