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目的：观察狗牙髓直接封蟾毒后牙髓内降钙素基因相关肽免疫反应阳性（简称ＣＧＲＰ－ＩＲ）神经纤维的动态变化。方法：采用冰冻切片和免疫组织化学方法（ＡＢＣ法）。结果：封药１ｈ，蟾毒组及可卡因组其牙髓内ＣＧＲＰ－ＩＲ神经纤维在形态、染色及数量上无显著差别；封药４ｈ，蟾毒组牙髓内ＣＧＲＰ－ＩＲ神经纤维明显断裂、数量减少、染色变浅，而可卡因组则无明显变化。结论：蟾毒快速麻痹牙髓神经的作用机理可能为一种神经毒性作用
OBJECTIVE: To observe the dynamic changes of CGRP-IR nerve fibers in the endodontic pulp treated with cinobufagin directly. Methods: Frozen sections and immunohistochemistry (ABC method) were used. Results: The encapsulated CGRP-IR nerve fibers were not significantly different in the encapsulation for 1 h, bufalin and cocaine groups in morphology, The quantity decreased, the staining became lighter, but the cocaine group had no significant change. Conclusion: The mechanism of bursal toxin rapid paralysis of the pulp nerve may be a neurotoxic effect