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本文采用基于有限元法的多物理场耦合技术对两种通道结构的自由流电泳芯片的电泳行为进行模拟。模拟结果指出在芯片自由流电泳过程中流体行为是该芯片分离性能的重要影响因素。二维深度通道结构的自由流电泳芯片其流体行为相较于一维深度通道自由流电泳芯片更为复杂,并可解决了一维深度通道自由流电泳芯片的局限性。二维深度通道自由流电泳芯片内的两种流体行为为实际操作提供了理论指导。
In this paper, we simulate the electrophoresis behavior of free-flow electrophoresis chips with two kinds of channel structures by using multiphysics coupled technology based on finite element method. The simulation results show that the fluid behavior during chip free flow electrophoresis is an important factor in the chip separation performance. Two-dimensional depth-channel structure of the free-flow electrophoresis chip flow behavior compared to the one-dimensional depth channel free-flow electrophoresis chip more complex and can solve the one-dimensional depth channel free flow electrophoresis chip limitations. Two-dimensional depth channel free-flow electrophoresis chip two kinds of fluid behavior provides a theoretical guide for the actual operation.