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目的:观测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及OSAHS合并牙周炎患者唾液中TNF-α、IL-6水平的变化。方法:将研究对象分为OSAHS合并牙周炎组40例,OSAHS无牙周炎组35例,单纯牙周炎组30例,正常对照组25例.用ELISA法检测并比较4组患者非刺激性全唾液中TNF-α,IL-6水平。结果:OSAHS合并牙周炎组中TNF-α、IL-6浓度显著高于其余各组,差异有统计学意义(P<0.05)。并且OSAHS合并牙周炎组唾液中TNF-α、IL-6与附着丧失(AL)成正相关(P<0.05)。结论:OSAHS中的炎症过程可能是促使牙周炎加重的重要因素,OSAHS的程度可预测牙周炎发生的危险性。
Objective: To observe the changes of saliva TNF-α and IL-6 in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and OSAHS with periodontitis. Methods: The subjects were divided into OSAHS with periodontitis group of 40 cases, OSAHS no periodontitis group of 35 cases, simple periodontitis group of 30 cases and normal control group of 25 cases.Using ELISA to detect and compare the 4 groups of patients with non-stimulation Sex full saliva TNF-α, IL-6 levels. Results: The levels of TNF-α and IL-6 in OSAHS with periodontitis group were significantly higher than those in other groups (P <0.05). And TNF-α and IL-6 in saliva of OSAHS with periodontitis were positively correlated with attachment loss (AL) (P <0.05). Conclusion: The inflammatory process in OSAHS may be an important factor to promote periodontitis. The degree of OSAHS can predict the occurrence of periodontitis.