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钙通道阻滞剂或钙拮抗剂的发现与应用为近年来心血管药物治疗的重要进展之一.钙桔抗剂最初出现于欧洲与日本,已广泛应用于治疗心绞痛,并以此作为线索,用于研究兴奋-收缩过程的基本理论,有关这一方面的兴趣在日益发展中.钙离子为兴奋-收缩耦联中的主要联系物质,而调节细胞内钙是调整心肌和平滑肌功能的关键.早从Ringer时代就已经知道钙离子的重要性,但只是最近5～10年才认识到钙离子的调节对理解肌肉的生理和病理生理是非常重要的基本概念.特殊调节蛋白如钙调素、磷酸受体(phospholamban)、向宁蛋白等的发现,肌凝蛋白轻链和在磷酸化过程中一些特异性激酶如环磷酸腺苷-蛋白激酶的重要作用的认识,都推动了这一方面的发展.生理学上的进展又启
The discovery and application of calcium channel blockers or calcium antagonists has been one of the important advances in cardiovascular drug therapy in recent years.Calcium citrate initially appeared in Europe and Japan and has been widely used in the treatment of angina and as a clue, Interest in this area is evolving, as the basic theory used to study the excitatory-contractile process, and calcium ion is the main contact material in excitatory-contractile coupling, and regulation of intracellular calcium is key to modulating cardiac and smooth muscle function. The importance of calcium has been known since the time of Ringer, but only in the last five to 10 years has it been recognized that the regulation of calcium ions is a fundamental concept that is important in understanding the physiology and pathophysiology of muscle. Special regulatory proteins such as calmodulin, Awareness of the important role of phospholamban, the discovery of ninjones and the like, myosin light chain, and some specific kinases such as cyclic AMPK during phosphorylation have contributed to this aspect Development. Physiological progress again Kai