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目的探讨分析新型隐球菌脑膜炎临床治疗经验与体会。方法 30例新型隐球菌脑膜炎患者,随机分为观察组和对照组,每组15例。对照组给予氟康唑治疗,观察组给予两性霉素B联合氟康唑治疗。观察对比两组患者的治疗效果及不良反应情况。结果经治疗后,对照组治疗总有效率为53.3%,观察组治疗总有效率为73.3%,观察组总有效率高于对照组,但两组差异无统计学意义(P>0.05)。结论联合用药治疗新型隐球菌脑膜炎的临床效果好,可以发挥抗真菌的作用,缓解患者的临床症状,改善患者预后,值得在临床治疗中推广应用。
Objective To investigate the clinical experience of Cryptococcus neoformans meningitis. Methods Thirty new cases of cryptococcal meningitis were randomly divided into observation group and control group, with 15 cases in each group. The control group was treated with fluconazole, the observation group was given amphotericin B combined with fluconazole treatment. Observed and compared the two groups of patients with treatment and adverse reactions. Results After treatment, the total effective rate of the control group was 53.3%. The total effective rate of the observation group was 73.3%. The total effective rate of the observation group was higher than that of the control group, but there was no significant difference between the two groups (P> 0.05). Conclusion Combined treatment of Cryptococcus neoformans meningitis has good clinical effect, can play an anti-fungal effect, relieve the clinical symptoms and improve the prognosis of patients, it is worth to promote the clinical application.