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目的:研究重症肺炎患者血清白细胞介素-2(IL-2)水平及与呼吸功能的相关性。方法:选择2013年5月~2016年5月在我院进行诊治的重症肺炎患者80例为观察组,同期在我院呼吸科入住的一般呼吸道感染患者80例为对照组,分别检测两组的血清IL-2水平,记录呼吸频率,取动脉血检测氧分压和氧合指数,采用单因素回归分析血清IL-2与呼吸功能的相关性。结果:观察组的血清IL-2水平明显高于对照组(P<0.05);观察组的呼吸频率明显高于对照组(P<0.05),氧分压和氧和指数均明显低于对照组(P<0.05);血清IL-2水平与呼吸频率呈明显正相关(P<0.05),与氧分压和氧和指数呈明显负相关(P<0.05)。结论:重症肺炎患者血清IL-2水平明显升高,且与呼吸功能密切相关,能作为判断重症肺炎患者呼吸功能的客观检查指标。
Objective: To study the correlation between serum interleukin-2 (IL-2) level and respiratory function in patients with severe pneumonia. Methods: Eighty patients with severe pneumonia diagnosed and treated in our hospital from May 2013 to May 2016 were selected as the observation group. 80 patients with common respiratory infections admitted to our Department of Respiratory Care during the same period were selected as the control group, Serum IL-2 levels, respiratory rate were recorded, the partial pressure of oxygen and oxygenation index were measured by arterial blood flow, and the correlation between serum IL-2 and respiratory function was analyzed by univariate regression analysis. Results: The level of IL-2 in the observation group was significantly higher than that in the control group (P <0.05). The respiratory rate in the observation group was significantly higher than that in the control group (P <0.05) (P <0.05). Serum IL-2 level was positively correlated with respiratory rate (P <0.05), and negatively correlated with partial pressure of oxygen and oxygen and index (P <0.05). Conclusion: Serum IL-2 levels are significantly elevated in patients with severe pneumonia and closely related to respiratory function, which can be used as an objective indicator of respiratory function in patients with severe pneumonia.