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狼疮带试验(LBT)指检查红斑狼疮(LE)皮损和系统性红斑狼疮(SLE)临床正常皮肤的真皮表皮交界(DEJ)处,免疫球蛋白(Ig)和补体(C)沉积的直接免疫荧光染色(DIF)方法。近年来有人认为从LE皮损取材特异性较差,LBT的活检部位应仅限于SLE临床正常皮肤,强调须区别LBT与LE皮损的蛋白沉积。SLE的预后与器官受累有关,其中肾损害是最重要的影响因素,判断预后主要是估计肾损害有无及其损害程度。LBT对SLE的诊断价值已趋肯定,但其判断预后的意义至今仍有较大争议。本文从以下几个方面综述LBT对判断SLE预后的价值。
Lupus Band Test (LBT) refers to the direct immunization of immunoglobulins (Ig) and complement (C) deposits at the dermis junction (DEJ) of the lupus erythematosus (LE) lesion and the systemic lupus erythematosus (SLE) Fluorescent staining (DIF) method. In recent years, some people think that the lesion from the LE lesion specificity is poor, LBT biopsy site should be limited to SLE clinical normal skin, emphasizing the need to distinguish between LBT and LE lesion protein deposition. The prognosis of SLE and organ involvement, of which kidney damage is the most important factor to determine the prognosis is mainly to assess the extent of renal damage and its extent. The diagnostic value of LBT on SLE has been certain, but its significance to determine the prognosis is still more controversial. This article summarizes the value of LBT in judging the prognosis of SLE from the following aspects.