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目的:探讨原发性及继发性闭经患者外周血细胞染色体异常及其临床意义。方法:对67例原发性及继发性闭经患者进行外周血淋巴细胞染色体培养,G显带,显微镜下核型分析。结果:在67例原发性及继发性闭经患者中共检出染色体异常20例,总异常率为29.85%。其中,38例原发性闭经患者中染色体异常17例,异常率44.74%;29例继发性闭经患者中染色体异常3例,异常率10.34%。包括染色体数目异常、嵌合、重复、缺失、异位及倒位。结论:染色体异常是导致原发性或继发性闭经的主要原因,对闭经患者外周血细胞进行染色体核型分析,对研究闭经的病因、估计患者预后和及时治疗具有十分重要的意义。
Objective: To investigate the chromosomal abnormalities of peripheral blood cells in patients with primary and secondary amenorrhea and its clinical significance. Methods: 67 cases of primary and secondary amenorrhea patients with peripheral blood lymphocyte chromosome culture, G band, karyotype analysis under the microscope. RESULTS: Totally 20 cases of chromosomal abnormalities were detected in 67 cases of primary and secondary amenorrhea, with a total abnormality rate of 29.85%. Of the 38 patients with primary amenorrhea, 17 were chromosomal abnormalities with an abnormality rate of 44.74%; 3 of 29 patients with secondary amenorrhea had chromosomal abnormalities with an abnormal rate of 10.34%. Including the number of chromosome abnormalities, chimerism, duplication, deletion, ectopic and inverted. Conclusion: Chromosomal abnormalities are the main cause of primary or secondary amenorrhea. Chromosomal analysis of peripheral blood cells in patients with amenorrhea is of great significance in studying the etiology of amenorrhea, estimating prognosis and timely treatment.