目的：评估伴有高风险因素的糖尿病性视网膜病变（ｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＤＲ）的眼底激光光凝疗效。方法：复习连续的２２例经或未经眼底激光治疗的ＤＲ玻切患者的临床资料，分析其４４只眼的预后。采用单个患者的双眼配对比较，对双眼行不同治疗（一眼行全视网膜光凝（ｐａｎｒｅｔｉｎａｌｐｈｏｔｏｃｏａｇｕｌａｔｉｏｎ，ＰＲＰ），对侧眼行局部光凝（ｆｏｃａｌｐｈｏｔｏｃｏａｇｕｌａｔｉｏｎ，ＦＰ）；或一眼行ＦＰ而对侧眼未行光凝）的，进行分组比较。结果：２２例４４眼中，行ＦＰ的１５眼中，１３只眼（８６．６７％）视网膜病变进展，玻璃体积血而需玻切治疗，２眼（１５．３８％）在随访期内新生血管萎缩，病变无明显进展；行ＰＲＰ的１１只眼中，２眼（１８．１８％）因玻璃体出血而玻切，９眼（６９．２３％）在随访期内新生血管萎缩，视网膜病变无明显进展；而在未行激光治疗的１８只眼中，６只眼失明（新生血管性青光眼），余１２只眼均因玻璃体积血、纤维增殖而玻切（其中９只眼有牵引性视网膜脱离）。ＰＲＰ组与ＦＰ组之间疗效存在显著差异（ｐ＜０．０５）。而ＦＰ组与未激光组之间无差异（ｐ＞０．３）结论：对具有血糖控制差、合并糖尿病性肾病、高血压 Objective: To evaluate the efficacy of fundus laser photocoagulation for diabetic retinopathy with high-risk factors. Methods: The clinical data of 22 consecutive patients with DR vitrectomy treated with or without fundus laser were reviewed, and the prognosis of 44 eyes was analyzed. A single patient’s binocular comparisons were performed on two eyes with different treatments (one with panretinal photocoagulation (PRP), the other with focal photocoagulation (FP); or one with FP and the other with unopposed eyes Condensate), for group comparison. Results: Of the 22 eyes (44 eyes), 13 (86.67%) of the 15 eyes underwent FP and the vitreous hemorrhage was treated by vitrectomy. Two eyes (15.38%) had neovascular atrophy during the follow-up period , No significant pathological changes. Of the 11 eyes with PRP, 2 eyes (18.18%) were vitrectomy due to vitreous hemorrhage, 9 eyes (69.23%) showed no atrophy of neovascularization during the follow-up period, Of the 18 eyes without laser treatment, 6 eyes were blind (neovascular glaucoma) and the other 12 eyes were vitrectomy due to vitreous hemorrhage and fibrosis (9 of them had traction retinal detachment). There was a significant difference between the PRP and FP groups (p <0.05). However, there was no difference between FP group and non-laser group (p> 0.3) .Conclusion: The patients with poor control of blood glucose, diabetic nephropathy,