LeRoy在1971年报告进行性硬皮病患者的成纤维细胞有较高细胞增殖率和高胶原合成率。另方面,Polish等(1976)在硬皮病和对照者的成纤维细胞之间则未发现胶原合成率有何明显差异。作者认为两个实验室的矛盾结果可能由于活体组织标本系取自进行性疾病的不同阶段之故。笔者报告一例晚期女病人,在作皮肤活体组织检查时已72岁。典型的硬皮病症状出现于55岁(1959)(雷诺氏现象,肢端和其他部分皮肤硬化、口小畸形,毛细血管扩张)。1964年患者首次住院并 LeRoy reported in 1971 that patients with progressive scleroderma had higher rates of cell proliferation and high rates of collagen synthesis in their fibroblasts. On the other hand, Polish et al. (1976) found no significant difference in the rate of collagen synthesis between scleroderma and control fibroblasts. The author believes that the contradictory results of the two laboratories may be due to the different stages of the progressive disease taken from the living tissue specimens. I report a case of late female patients, for skin biopsy has been 72 years old. Typical scleroderma symptoms occur at the age of 55 (1959) (Raynaud’s phenomenon, acral and other parts of the skin sclerosis, small deformities, telangiectasias). In 1964, the patient was hospitalized for the first time