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目的】分析脑缺血时单胺类神经递质代谢变化的规律并比较其敏感性。【方法】结扎成年蒙古沙土鼠左侧颈总动脉建立脑缺血动物模型 ,以动脉假手术为对照组 ,采用高效液相色谱法 ,测定脑缺血 6h新皮层内去甲肾上腺素 (NE)、多巴胺 (DA )、5 羟色胺 ( 5 HT )、3 ,4 二羟基苯乙酸 (DOPAC)、高香草酸 (HVA )、5 羟吲哚乙酸 ( 5 HIAA )、色氨酸 (Trp)含量。【结果】结扎侧单胺递质含量显著降低 ,其代谢产物含量显著升高 ;结扎对侧也有类似的变化。【结论】单胺递质及其代谢产物水平的变化多数与缺血症状严重程度密切相关。多因素分析发现其中NE水平变化最明显。
Objective] To analyze the changes of monoamine neurotransmitter metabolism in cerebral ischemia and compare its sensitivity. 【Methods】 Adult male Mongolian gerbils were ligated into the left common carotid artery to establish a model of cerebral ischemia. Arterial sham operation was used as a control group. The levels of norepinephrine (NE) , DA, 5 HT, DOPAC, HVA, 5 HIAA and Trp were determined. 【Results】 The content of monoamine neurotransmitters on the ligation side was significantly decreased, and the metabolites content was significantly increased. Similar changes were also observed on the opposite side of ligation. 【Conclusion】 The changes of monoamine neurotransmitters and their metabolites are closely related to the severity of ischemic symptoms. Multivariate analysis found that the most obvious change in NE levels.