The objective of this investigation was to compare the fatigue properties of friction stir welds with those of MIG-pulse welds. The 5083 Al-Mg alloy was welded by single pass friction stir welding(FSW) and double-sided MIG-pulse welding. The results show that friction stir(FS) welds have a better appearance than MIG-pulse welds for the lack of voids, cracks and distortions. Compared with the parent plate, FSW welds exhibit similar fine grains, while MIG-pulse welds display a different cast microstructure due to the high heat input and the addition of welding wire. The S-N curves of FSW and MIG-pulse joints show that the fatigue life of FS welds is 18 - 26 times longer than that of MIG-pulse welds under the stress ratio of 0.1 and the calculated fatigue characteristic values of each weld increase from 38.67 MPa for MIG-pulse welds to 53.59 MPa for FSW welds.