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前列腺素(PG)几乎能由体内所有组织合成。其生理作用十分广泛,效价极高,特别是体内PG 缺乏或过量可能与许多疾病或病理过程密切相关。PG 生物合成概述PG 是一族含有一个五元环及二条侧链结构的20碳不饱和脂肪酸。PG 的前体是构成细胞膜磷脂的多价不饱和脂肪酸,主要是二十碳四烯酸(花生四烯酸),另外还有二种含量较少的脂肪酸即二十碳三烯酸(二高-γ-亚麻酸)及二十碳五烯酸。它们分别合成PG_2、PG_1及PG_3类。根据五元环的取代基及双键的位置不
Prostaglandins (PGs) are synthesized by almost all tissues in the body. Its physiological role is very broad, high potency, especially in vivo PG deficiency or excess may be closely related to many diseases or pathological processes. PG Biosynthesis Overview PG is a family of five-membered ring and two side chain structure of 20-carbon unsaturated fatty acids. The precursors of PG are polyunsaturated fatty acids that make up the cellular membrane phospholipids, mainly arachidonic acid (arachidonic acid), as well as two less fatty acids, eicosatrienoic acid -γ-linolenic acid) and eicosapentaenoic acid. They synthesized PG_2, PG_1 and PG_3 respectively. According to the five-membered ring substituents and double bond position is not