鲎热原试剂(Pyrogent试剂)即鲎变形细胞溶解物(Limulus Amebocyte Lysate简称LAL)可用于定性检测革兰氏阴性细菌细胞壁内热原成分的存在,并可定量检测该内毒素的浓度。目前这种鲎试剂作为一灵敏、可靠而又节约的方法已用于注射剂工业中日常大量无热原水的检测。美国食物和药品管理局(FDA)已批准应用鲎试剂代替美国药典热原试验作为部分注射剂中间产品的热原控制。鲎试验的生物化学基础 Pyrogent Reagents Limulus Amebocyte Lysate (LAL) can be used to qualitatively detect the presence of pyrogen components in the cell walls of Gram-negative bacteria and quantify the endotoxin concentration. At present, this reagent is used as a sensitive, reliable and economical method for the detection of a large number of daily pyrogen-free water in the injection industry. The U.S. Food and Drug Administration (FDA) has approved the use of Reagent Reagents instead of the USP pyrogen test as a pyrogen control for some injection intermediate products.鲎 test biochemical basis