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目的探讨幽门螺杆菌(Hp)在胃癌淋巴转移中的作用。方法应用免疫组化方法检测80例胃癌标本中D2-40的表达情况并计数淋巴管密度(lymphatic vessel density,LVD),改良Giemsa染色法检测Hp。结果胃癌标本Hp阳性率为66.25%。有淋巴结转移胃癌标本LVD(15.11±7.30)高于无淋巴结转移标本LVD(10.67±3.80),差异有统计学意义(P<0.05)。Hp阳性胃癌标本LVD(16.33±6.89)高于Hp阴性胃癌标本LVD(9.10±3.10),差异有统计学意义(P<0.05)。胃癌标本中LVD在不同的性别、年龄、组织学分化程度、临床分期的差异无统计学意义。结论 Hp可能对胃癌的淋巴转移起促进作用。
Objective To investigate the role of Helicobacter pylori (Hp) in lymphatic metastasis of gastric cancer. Methods Immunohistochemistry was used to detect the expression of D2-40 in 80 gastric cancer specimens and the lymphatic vessel density (LVD) was counted. Hp was detected by modified Giemsa staining. Results The positive rate of Hp in gastric cancer specimens was 66.25%. The LVD (15.11 ± 7.30) in gastric cancer with lymph node metastasis was higher than that in non-lymph node metastasis (10.67 ± 3.80), the difference was statistically significant (P <0.05). The LVD (16.33 ± 6.89) in Hp positive gastric cancer specimens was higher than that in Hp negative gastric cancer specimens (9.10 ± 3.10), the difference was statistically significant (P <0.05). The difference of LVD in different gender, age, histological differentiation and clinical stage in gastric cancer specimens was not statistically significant. Conclusion Hp may promote lymphatic metastasis of gastric cancer.