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目的:研究群体反应性抗体(PRA)对再次肾移植患者移植肾长期存活和肾功能的影响。方法:采用美国GTI公司提供的ELISA筛选HLA-I类、Ⅱ类混合抗原板,对59例再次肾移植患者进行PRA检测。鉴定抗体类型采用美国One lanmbda公司鉴定抗原板(LAT.1240)。同时检测移植肾功能。结果:59例再次肾移植患者中,抗体阳性患者16例,占27.12%(16/59),其中抗HLA-I类抗体3例,占5.08%(3/59),抗HLA-II类抗体9例,占15.25%(9/59),抗HLA-I+II类抗体4例,占6.78%(4/59)。抗体阳性与抗体阴性患者比较,肾功能下降或丧失具有显著性差异(x2=33.634,P<0.001)。结论:抗HLA抗体阳性是影响再次肾移植患者移植肾长期存活的重要因素。
Objective: To investigate the effect of population reactive antibody (PRA) on long-term graft survival and renal function in renal transplant recipients. Methods: HLA-I and II mixed antigen plates were screened by ELISA from GTI Company of America and PRA was performed in 59 cases of re-renal allografts. Identification of antibody types using the United States One lanmbda company identification antigen plate (LAT.1240). Simultaneous detection of graft function. Results: Sixteen patients (27.12% (16/59)) with anti-HLA-I antibody were found in 59 renal transplant recipients, including 3 anti-HLA class I antibodies (5.08%, 3/59) 9 cases, accounting for 15.25% (9/59), anti-HLA-I + II antibody in 4 cases, accounting for 6.78% (4/59). Antibody positive and antibody negative patients, decreased or loss of renal function was significantly different (x2 = 33.634, P <0.001). Conclusion: The positive anti-HLA antibody is an important factor that affects the long-term survival of transplanted kidneys in patients undergoing renal transplantation.