Circulation杂志2014年6月13日在线发表的一项研究发现,糖尿病心衰患者左心房心肌线粒体呼吸减少,氧化应激增加,表明线粒体功能障碍在糖尿病心衰病理生理过程中扮演着一定的角色。无独有偶,心脏线粒体功能障碍和氧化损伤与肥胖之间也存在关联。但由于肥胖和高血糖之间存在重叠,上述研究无法严格意义上区分线粒体功能改 A study published online June 13, 2014 by Circulation magazine found that mitochondrial respiration and oxidative stress were increased in left atrial myocardium in patients with diabetic heart failure, suggesting that mitochondrial dysfunction plays a role in the pathophysiology of diabetic heart failure. Coincidentally, there is also a correlation between cardiac mitochondrial dysfunction and oxidative damage and obesity. However, due to the overlap between obesity and hyperglycemia, the above studies can not strictly distinguish between mitochondrial function