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肌萎缩侧索硬化(ALS)和特发性帕金森氏征(IP)均为神经系统的慢性退行性病变,据此推测,ALS患者黑质纹状体多巴胺能通路有亚临床损害,作者用正电子发射扫描(PET)对此进行研究。 16例患者,平均年龄60.4岁(49～70)。ALS诊断依据临床及肌电图有上、下运动神经原损害,排除锥体外系病变及痴呆。半年内未服用神经安定药物。病程42.2月(9～168)。正常对照13例,年龄匹配。方法:扫描前一小时用卡比多巴100mg,造影时静注6—氟多巴(6—fluorodopa),摄片过程中连续静脉采血测量放射性总量。 结果发现纹 状体6—fluorodopa吸收比率与年
Amyotrophic lateral sclerosis (ALS) and idiopathic Parkinson’s sign (IP) are chronic degenerative diseases of the nervous system. Therefore, we hypothesized that subclinical dopaminergic lesion of nigrostriatal pathway may be associated with subclinical lesion in ALS. Positron emission tomography (PET) studies this. Sixteen patients, mean age 60.4 years (49-70). ALS diagnosis based on clinical and electromyography have upper and lower motor neuron damage, excluding extrapyramidal lesions and dementia. Within six months did not take neuroleptic drugs. Duration of 42.2 months (9 ~ 168). Normal control in 13 cases, age-matched. METHODS: One hour before scanning, 100 mg of carbidopa was administered intravenously and 6-fluorodopa intravenously during angiography. The total radioactivity was measured by continuous venous blood sampling during radiography. The results showed striatal 6-fluorodopa uptake ratio with years