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在研究各种利尿药对尿中锂排出的药理学作用时发现口服1克氨茶碱(0.79克茶碱)就可使锂的排出量增加。咖啡因及黄嘌呤亦有类似作用。因此,研究者提出可用氨茶碱来治疗锂中毒。当锂与茶碱并用时锂的肾廓清率(CILi)增加,故就需增加锂的治疗剂量以滋补偿,然而究竟需增加多少剂量,故在重症锂中毒治疗时静脉注射茶碱CIL是否足以替代血液透析疗法。为此,作者对i茶碱在稳定血浓度时对CILi的影响进行研究。作者挑选了10例健康成年人为研究对象(男6例、女5例)。年龄为18～55岁,他们没有肾疾病、消化性溃疡、重症高血压和吸烟史;血清肌酐、肌酐廓清率以及其他临床
In studying the pharmacological effects of various diuretics on urinary lithium excretion, 1 gram of aminophylline (0.79 grams of theophylline) was orally administered to increase the amount of lithium excreted. Caffeine and xanthine also have similar effects. Therefore, the researchers proposed that aminophylline may be used to treat lithium poisoning. When lithium and theophylline with lithium renal clearance rate (CILi) increased, so the need to increase the dose of lithium in order to compensate for the loss of compensation, but how much need to increase the number of doses, so in the treatment of severe lithium poisoning intravenous theophylline CIL is sufficient Alternative to hemodialysis. For this reason, the authors studied the effect of i theophylline on CILi when stabilizing blood concentrations. The authors selected 10 healthy adults as study subjects (6 males and 5 females). They are 18-55 years old and have no history of kidney disease, peptic ulcer disease, severe hypertension, and smoking. Serum creatinine, creatinine clearance, and other clinical