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目的：了解Ｐ－糖蛋白（Ｐｇｐ）及多药耐药相关蛋白（ＭＲＰ）在胃癌中的表达与意义．方法：采用免疫组化ＳＡＢＣ法．结果：在４３例胃癌中，Ｐｇｐ及ＭＲＰ阳性者分别为１３例（３０．２％），２２例（５１．２％）；在４３例相应癌旁组织中分别为８例（１８．６％），１７例（３９．５％）；而在３０例胃炎组织中则分别为５例（１６．７％），９例（３０．０％）．Ｐｇｐ与ＭＲＰ表达均阳性者，癌组织４例（９．３％），癌旁组织１例（２．３％），胃炎组织０例．Ｐｇｐ在已发生淋巴或血行转移病例中表达者（１１例），明显高于无淋巴或血行转移者（２例）；Ｐｇｐ或ＭＲＰ的表达与患者年龄、性别、癌的病理类型等均无相关性．结论：Ｐｇｐ及ＭＲＰ在胃癌中的较高表达，而Ｐｇｐ的阳性表达提示癌已进入晚期
Objective: To investigate the expression and significance of P-glycoprotein (Pgp) and multidrug resistance-related protein (MRP) in gastric cancer. Methods: immunohistochemical SABC method. Results: Among the 43 cases of gastric cancer, Pgp and MRP were positive in 13 (30.2%) and 22 (51.2%) patients, respectively, in 43 cases of paracancerous tissues (8 cases, 18.6% ), 17 cases (39.5%); while in 30 cases of gastritis were 5 cases (16.7%), 9 cases (30.0%). Pgp and MRP were positive in 4 cases (9.3%), paracancer tissue in 1 case (2.3%) and gastritis in 0 cases. The expression of Pgp in lymphatic or hematogenous metastasis cases (11 cases) was significantly higher than that in non-lymphatic or hematogenous metastasis cases (2 cases). The expression of Pgp or MRP was not related to the age, sex and pathological type of cancer Sex. Conclusion: Pgp and MRP are highly expressed in gastric cancer, while the positive expression of Pgp suggests that the cancer has entered advanced stage