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骨质疏松症是一种常见的代谢性骨病,表现为骨痛、多发性骨质和骨密度降低等,易发生骨折,多发于老年人和绝经后的妇女,严重影响患者的生活质量。骨质疏松的发病机制尚不明确,尚无特效治疗方法。本研究通过以氟及氟加钙饲喂骨质疏松模型大鼠,观察骨密度和骨组织形态学变化,为氟治疗骨质疏松提供实验数据。1材料与方法1.1模型制备和分组采用去卵巢法建立骨质疏松模型。选择雌性SD大鼠,3月龄,体重200~250 g,共
Osteoporosis is a common metabolic bone disease, manifested as bone pain, multiple bone and bone mineral density decreased, prone to fracture, mainly in the elderly and postmenopausal women, seriously affecting the quality of life of patients. The pathogenesis of osteoporosis is not clear, there is no effective treatment. In this study, fluoride and fluoride plus calcium fed osteoporosis model rats, observed bone mineral density and bone morphological changes, experimental data for the treatment of osteoporosis fluoride. 1 Materials and Methods 1.1 Model Preparation and Grouping ovariectomized osteoporosis model. Female SD rats were selected, 3 months old, weighing 200 ~ 250 g, total