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H2 O2 对细胞膜上不同的离子通道有广泛的作用 ,而且同一种通道在不同的组织类型中对H2 O2 的反应性亦不同。在培养的lymnaea(椎螺 )神经元中 ,H2 O2 可诱导剂量依赖性的内向Ca2 +电流的降低 ,L 型Ca2 +电流的降低 ,导致通道失活。在绵羊心肌细胞的内质网H2 O2 可直接调节Ca2 +释放通道 ,使其开放概率 (P0 )增加 ,但它不影响电导。H2 O2对K+通道的作用表明 ,H2 O2 介导的KCa通道活性改变因组织类别的不同而亦有差异。H2 O2 可诱导豚鼠心肌细胞ATP 敏感K+通道的活动增加。H2 O2 对全细胞Na+通道的影响及对单通道Na+电流的影响目前报道极少
H2O2 has a wide range of different ion channels on the cell membrane, and the same channel in different tissue types of H2O2 reactivity is also different. In cultured lymnaea neurons, H2O2 induced a dose-dependent reduction of inward Ca2 + currents and a decrease of L-type Ca2 + currents, resulting in channel inactivation. H 2 O 2 in the endoplasmic reticulum of sheep cardiocytes directly regulates the Ca 2+ release channel and increases its open probability (P0), but it does not affect the conductance. The effect of H2 O2 on the K + channel suggests that H2O2-mediated changes in KCa channel activity vary by tissue type. H2 O2 induces an increase in ATP-sensitive K + channels in guinea pig cardiomyocytes. The effect of H2O2 on whole cell Na + channel and its effect on single channel Na + current is rarely reported