氯霉素的毒性反应主要在骨髓,对内耳的有害作用极少报道,本文报道1例。患者女,20岁,因患伤寒和发热先后两次全身用氯霉素治疗,前后间隔二月余。剂量为500mg,每6小时一次。第一次用17日;第二次用1周。用药后双耳听力进行性减退,最后导致双侧极度感觉神经性聋;冷热水试验反应消失。 Chloramphenicol toxicity is mainly in the bone marrow, the deleterious effects on the inner ear rarely reported, this article reported 1 case. Female patient, 20 years old, has chloramphenicol treatment twice as a result of typhoid fever and fever, before and after more than two months apart. The dose is 500 mg every 6 hours. The first with 17 days; the second with 1 week. After hearing the binaural hearing loss, eventually leading to bilateral extreme sensory nerve deafness; hot and cold water reaction disappeared.