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防御素(defensin)是一类相对分子质量为(4.0~5.0)×103且富含氨基酸残基的阳离子抗菌肽。对革兰阴性菌、分枝杆菌、真菌等有很强的杀伤活性,在哺乳动物固有免疫中起着重要作用。人β-防御素-2(humanβ-defensin-2,HBD-2)是人体中第一个被发现的可诱导性表达的防御素,主要来源于皮肤角质细胞、黏膜上皮细胞,在皮肤、黏膜的固有免疫功能中具有重要作用。对细菌、真菌、病毒等微生物均有很强的杀伤活性。与多种疾病的免疫病理机制密切相关。迄今为止,在人体内已
Defensins are a class of cationic antimicrobial peptides with a relative molecular mass of (4.0 ~ 5.0) × 103 and rich in amino acid residues. Gram-negative bacteria, mycobacteria, fungi and other strong killing activity, play an important role in mammalian innate immunity. Human beta-defensin-2 (HBD-2) is the first inducible expression of inducible defensins in the human body, mainly derived from skin keratinocytes, mucosal epithelial cells, Of the innate immune function has an important role. On bacteria, fungi, viruses and other microorganisms have a strong killing activity. With a variety of diseases is closely related to the immune pathology. So far, in the human body has been