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目的:探讨血清胃蛋白酶原Ⅰ/Ⅱ(PGⅠ/Ⅱ)、铁蛋白、肿瘤坏死因子-α联合检查诊断胃癌的临床意义。方法:选择2013年5月至2014年10月收治的胃病住院患者及健康体检者,根据胃镜及病理组织学结果,将其分良性胃病组、胃癌组以及健康组,比较三组血清胃蛋白酶原Ⅰ/Ⅱ、铁蛋白及肿瘤坏死因子-α水平,分析血清胃蛋白酶原Ⅰ/Ⅱ(PGⅠ/Ⅱ)、铁蛋白、肿瘤坏死因子-α单独和联合诊断胃癌的敏感性、特异性和准确性。结果:与健康组比较,良性胃病组以及胃癌组的血清PGⅠ/Ⅱ水平较低(P<0.05),与良性胃病组比较,胃癌组血清PGⅠ/Ⅱ水平较低(P<0.05);与健康组比较,良性胃病组以及胃癌组的血清铁蛋白以及TNF-α水平较高(P<0.05),与良性胃病组比较,胃癌组血清铁蛋白以及TNF-α水平较高(P<0.05)。PGⅠ/Ⅱ、铁蛋白以及TNF-α联合检测诊断胃癌的敏感度以及准确度分别为88.4%以及83.1%,高于单一检测。结论:血清PGⅠ/Ⅱ、血清铁蛋白、肿瘤坏死因子-α联合检测诊断胃癌的效能优于单一检测。
Objective: To investigate the clinical significance of combined detection of serum pepsinogen Ⅰ / Ⅱ (PGⅠ / Ⅱ), ferritin and tumor necrosis factor-α in the diagnosis of gastric cancer. Methods: Gastric inpatients and healthy subjects who were admitted to our hospital from May 2013 to October 2014 were selected. According to gastroscopy and histopathological results, the patients were divided into benign and gastric diseases group, gastric cancer group and healthy group. The levels of serum pepsinogen To investigate the sensitivity, specificity and accuracy of serum pepsinogen Ⅰ / Ⅱ (PGⅠ / Ⅱ), ferritin and tumor necrosis factor-α in the diagnosis of gastric cancer . Results: Compared with healthy group, the serum PGⅠ / Ⅱ level in benign gastric disease group and gastric cancer group was lower (P <0.05), and the serum PGⅠ / Ⅱ level in gastric cancer group was lower than that in benign gastric disease group (P <0.05) The level of serum ferritin and TNF-α were higher in benign gastric disease group and gastric cancer group (P <0.05). The levels of serum ferritin and TNF-α in gastric cancer group were higher than those in benign gastric disease group (P <0.05). The sensitivity and accuracy of combined detection of PGⅠ / Ⅱ, ferritin and TNF-α in gastric cancer were 88.4% and 83.1% respectively, higher than that of single detection. Conclusion: The combined detection of serum PG Ⅰ / Ⅱ, serum ferritin and tumor necrosis factor-α is superior to single detection in the diagnosis of gastric cancer.