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自从红霉素问世28年以来,在广泛的临床应用中已证明它是安全和有效的。直到最近,发现红霉素还具有其它治疗作用时,它的应用范围才有所扩大,可惜也出现了新的毒性。 1976年,在美国费城退伍军人集会的人群中,肺炎发生了明显的流行,以后又鉴定出了病源菌并做了药物敏感试验,引起了对红霉素的重新重视。红霉素除了被公认为能治疗嗜肺军团菌(Legionella pneumophila)引起的肺炎外,近年来又发现了它还具有其它适应症,因此,增加了此药的临床应用。与这些发展相比较,近年来虽然有关此药副作用的报道较少见,但偶有严重副作用的报
Erythromycin has been shown to be safe and effective in a wide range of clinical applications for 28 years since its inception. Until recently, erythromycin was found to have other therapeutic benefits as its scope of application expanded only to the detriment of new toxicities. In 1976, a significant epidemic of pneumonia occurred in the crowd of veterans from the Philadelphia, United States. Later identification of pathogenic bacteria and drug susceptibility testing led to a renewed emphasis on erythromycin. In addition to being recognized as being able to treat pneumonia caused by Legionella pneumophila, erythromycin has also been found to have other indications in recent years, thus increasing its clinical utility. In contrast to these developments, reports of side effects of this drug are rare in recent years, but reports of occasional serious side effects