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Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factor-inhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show thathydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.
Three interaction with factor-inhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show thathydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.