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对霉菌毒素毒性的研究,除黄曲霉毒素(AFT)外,主要在成年动物上进行。由于缺少霉菌毒素对幼年动物作用的资料,本文作者介绍了AFT-B_1、棕曲霉毒素A和红青霉毒素B对新生大鼠毒性作用的研究。作者用生后24小时的Sprague-Dawley大鼠测定AFT-B_1,棕曲霉毒素A和红青霉毒素B的LD_(50)值。新生大鼠观察7天,AFT-B_1,棕曲霉毒素A和红青霉毒素B的口服LD_(50)值分别为1.36、3.90和6.38mg/kg。成年大鼠对新生鼠LD_(50)的比值,AFT-B_1为9.2、棕曲
Studies on the mycotoxin toxicity, except aflatoxins (AFTs), are mainly performed on adult animals. Due to the lack of information on the effects of mycotoxins on juvenile animals, the authors describe the toxic effects of AFT-B_1, aspergillus toxin A and rubraxin B on neonatal rats. The authors measured the LD 50 value of AFT-B 1, the aflatoxin A and the red Penicillin B using Sprague-Dawley rats 24 hours after birth. Oral LD_ (50) values of AFT-B_1, aflatoxin A and rubellaxin B were 1.36, 3.90 and 6.38 mg / kg, respectively, for 7 days in neonatal rats. Adult rats on newborn rat LD_ (50) ratio, AFT-B_1 of 9.2, brown song