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目的 :观察国产氟康唑对血液系统恶性疾病伴发真菌感染的治疗作用 ,同期与进口氟康唑 (大扶康 )对照。方法 :确诊或疑及真菌感染伴发热患者 99例 ,随机分为两组 ,治疗组 4 5例 ,予国产氟康唑 0 .2givdqd用药5～ 18d不等 ,对照组 5 4例 ,予大扶康 10 0mgivd ,bid用药 5～ 2 0d不等。结果 :治疗组和对照组应用药物后均较满意 ,有效率 >70 % ,两组比较无统计学意义 ,但成本 效果分析比较差异显著 (P <0 .0 1)。结论 :国产氟康唑治疗血液系统恶性疾病伴真菌感染有效、安全、可靠 ,较同类进口制剂更具备经济竞争力。
Objective: To observe the therapeutic effect of domestic fluconazole on malignant hematological malignancies associated with fungal infection, and to compare with imported fluconazole (Daifukang) during the same period. Methods: Ninety-nine patients with confirmed or suspected fungal infection and fever were randomly divided into two groups. The treatment group was 45 cases. The domestic fluconazole 0.2givdqd ranged from 5 to 18 days. The control group received 54 cases, Kang 10 0 mgivd, bid medication 5 ~ 20d range. Results: The treatment group and the control group were satisfied with the application of drugs, the effective rate was> 70%, the two groups were not statistically significant, but the cost-effectiveness analysis was significantly different (P <0.01). Conclusion: Domestic fluconazole is effective, safe and reliable for the treatment of malignant hematological malignancies with fungal infection and more economical than the imported preparations.