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先前作者发现,无需添加佐剂,肺炎球菌表面蛋白A(PspA)与伤寒沙门菌Vi荚膜多糖结合可增强抗PspA的免疫应答。目前研究由PspA家族1或2的α螺旋区结合到Vi多糖组成结合物用于免疫小鼠,以检测它抗静脉注射的能致死的肺炎链球菌各种菌株的能力。包含PspA家族1成分的结合疫苗对PspA家族1菌株的攻击提供了良好的保护作用,但对PspA家族2菌株的攻击没有保护作用。同样,
Previous authors found that the combination of pneumococcal surface protein A (PspA) with S. typhi Vi capsular polysaccharide without the addition of an adjuvant enhanced the immune response against PspA. Current studies have demonstrated that the ability to bind various strains of anti-intravenous, lethal S. pneumoniae is tested by the binding of the alpha helix region of the PspA family 1 or 2 to the Vi polysaccharide conjugate for immunization of mice. The conjugate vaccine containing the PspA family 1 component provided good protection against challenge with the PspA family 1 strain but had no protective effect against challenge with the PspA family 2 strain. same,