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以大鼠大脑中动脉阻塞２４小时后的梗塞面积和体积为指标，试验了汉防己碱和１，６┐二磷酸果糖对大鼠局部脑缺血的保护作用。在大脑中动脉阻塞后，汉防己碱７．５，１２．０和１５．０ｍｇ·ｋｇ┐１以及１，６┐二磷酸果糖２００和３５０ｍｇ·ｋｇ┐１分别立即腹腔给药，以剂量依赖方式明显减少大鼠脑的梗塞面积和体积。ＭＫ８０１２．０ｍｇ·ｋｇ┐１亦能减少梗塞面积和体积。汉防己碱和１，６┐二磷酸果糖联合用药所产生的保护作用比任何一药物单用时的保护作用都好，提示汉防己碱和１，６┐二磷酸果糖有协同作用。在大脑中动脉阻塞后１小时和２小时给药，汉防己碱和１，６┐二磷酸果糖仍有脑缺血保护作用，但在梗塞后３小时给药则未见任何保护作用。提示中风或脑缺血后，既非５分钟即不可救药，但亦应尽早用药。实验结果表明汉防己碱和１，６┐二磷酸果糖可能是有希望的脑缺血保护剂。
The cerebral infarction in rats 24 hours after the infarct size and volume as an indicator of tetrandrine and 1,6,6-diphosphate fructose on rat focal cerebral ischemia protective effect. After middle cerebral artery occlusion, tetrandrine 7.5, 12.0 and 15.0 mg · kg -1 and fructose 1,6 and 1,6-diphosphate 200 and 350 mg · kg -1 were administered intraperitoneally immediately, respectively, in a dose-dependent manner Significantly reduce infarct size and volume in rat brain. MK8012.0mg · kg┐1 can also reduce infarct size and area. The combination of tetrandrine and fructose 1,6 diphosphate had a protective effect better than either drug alone, suggesting that tetrandrine and fructose 1,6 diphosphate had synergistic effects. Administration of tetrandrine and fructose-1,6 diphosphate remained ischemic after 1 and 2 hours of occlusion of the middle cerebral artery, but no protective effect was observed 3 hours after infarction. Tip stroke or cerebral ischemia, neither 5 minutes is not hopeless, but should also be medication as soon as possible. Experimental results show that tetrandrine and fructose 1,6 diphosphate may be promising cerebral ischemia protective agent.