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作者报告了47例晚期头颈鳞癌患者应用顺铂、长春新硷及博菜霉素三联化疗的效果.48例Ⅲ、Ⅶ期头颈鳞癌患者,其中47例为可切除的肿瘤,1例为T_4 N_1 鼻咽癌.1例患者第一疗程后死于心肌梗死,故47例可分析疗效.化疗方案为:第一天晚上,用5%右旋糖苷十0.45%盐水(含20mEg/升氯化钾)以125毫升/小时速度静滴.给药后继续水化.化疗第一天给顺铂80mg/m~2,甘露醇12.5g.第二天给长春新硷1.4mg/m~2(最大量2.0mg/m~2),6小时后继续静滴博菜霉素15mg/m~2/天共5天.第一疗程结束后出院,两周后再次入院,开始第二疗程.化疗完成后2——14天内进行手术。若进行放疗,则在化疗后2——3周开始1.
The authors reported the efficacy of triplet chemotherapy with cisplatin, vinorelbine, and ampicillin in 47 patients with advanced head and neck squamous cell carcinoma. Of the 48 patients with stage III and VII squamous cell carcinoma of the head and neck, 47 were resectable tumors, and 1 was T_4 N_1 Nasopharyngeal carcinoma. One patient died of myocardial infarction after the first course of treatment, so 47 cases could be analyzed for efficacy. The chemotherapy regimen was: on the first night, with 5% dextran ten 0.45% saline (containing 20mEg/liter chlorine Potassium) was instilled at a rate of 125 ml/hour. Hydration continued after administration. Chemotherapy was given on the first day of cisplatin 80 mg/m 2 and mannitol 12.5 g. On the second day, Changchun Xinjing 1.4 mg/m 2 (Maximum 2.0mg/m~2), after 6 hours, continued intravenous draconycin 15mg/m~2/day for 5 days. After the first course of treatment was discharged, two weeks later, was admitted again and started the second course of treatment. The surgery is performed within 2 to 14 days after the completion of chemotherapy. If radiotherapy is performed, begin 2-3 weeks after chemotherapy.