美国孟菲斯市圣朱德儿童研究医院的John Schuetz及其同事声称,某种耐受抗HIV的治疗有可能是一种T淋巴细胞中耐多种药物的蛋白4(MRP4)过度表达的结果。这种过度表达可引起HIV逆转录酶强效抑制剂二脱氧核苷类从细胞中的流出,然后,细胞内药物浓度的降低不足以阻止病毒的复制。该结果可使某些病人对抗病毒治疗产生抵抗力,即使他们尚未感染上耐药病毒株。 John Schuetz and colleagues at St. Jude Children’s Research Hospital in Memphis, U.S.A., claim that some anti-HIV treatment may be the result of overexpression of multidrug resistant protein 4 (MRP4) in T lymphocytes. This over-expression can cause efflux of the dideoxynucleosides, a potent HIV reverse transcriptase inhibitor, from the cells, and then the decrease in intracellular drug concentration is not sufficient to prevent viral replication. This result may make some patients resistant to the virus treatment, even though they have not been infected with the resistant virus strain.