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目的观察米索前列醇联合催产素预防产后出血的疗效。方法选择110例单胎足月自然分娩,无前列腺素应用禁忌证的孕妇。随机分为两组,每组各55例,对照组采用催产素治疗,治疗组采用米索前列醇联合催产素治疗,比较两组治疗效果及不良反应发生情况。结果两组产妇第三产程时间相比,治疗组较对照组短,差异有统计学意义(P<0.05),产后2h出血量、产后24h出血量、产后出血发生率相比,治疗组均较对照组低,差异有统计学意义(P<0.05)。结论米索前列醇联合催产素可使第三阶段的产程时间缩短,预防产后出血的效果好,值得在临床实践中应用。
Objective To observe the effect of misoprostol combined with oxytocin in preventing postpartum hemorrhage. Methods One hundred and ten pregnant women with single-term full-term pregnancy were enrolled in this study. Pregnant women without prostaglandin contraindication were selected. Randomly divided into two groups, each with 55 cases in each group. The control group was treated with oxytocin. The patients in the treatment group were treated with misoprostol plus oxytocin. The therapeutic effects and adverse reactions were compared between the two groups. Results Compared with the control group, the treatment group was shorter than the control group (P <0.05), the amount of bleeding after 2 hours of postpartum, the amount of bleeding after 24 hours and the incidence of postpartum hemorrhage The control group was low, the difference was statistically significant (P <0.05). Conclusion Combination of misoprostol and oxytocin can shorten the stage of labor during the third stage and prevent postpartum hemorrhage. It is worth to be used in clinical practice.