对文山州麻风病人的家属及一般居民做了第３年的血清学随访；共７５６人，其中初次抗体阳性的居民和病人家属分别为１８４人和１３５人，初次抗体阴性的居民和家属分别为３１７人和１２９人。本次随访中初次抗体阳性的居民和病人家属分别有５５人（２９．９％）和２０人（１４．８％）仍为阳性；初次阴性的居民和家属分别有４７人（１４．８％）和１１人（８．５２）变为阳性。随访３年共有１１人发病，其中ＢＴ３人，ＢＬ８人。８例ＢＬ发病时抗体均为阳性，其中７例初次检查抗体亦阳性，６例滴度逐渐升高；出现阳性分割值到发病的平均时间为２６个月；３例ＢＴ中１例初次抗体阳性。但发病时均为阴性。作者认为在发病率较高的村庄，以血清学初筛加上对高滴度抗体者做皮肤查菌，隔２年左右再对初次抗体阳性者做血学随访，可能有助于发现多菌型病人，但在现场作为常规也许是不适宜的。 Serological follow-up of the family members and general residents of leprosy patients in Wenshan Prefecture for the third year was conducted; a total of 756 persons, including the first antibody-positive residents and their families were 184 and 135, respectively, and the primary antibody-negative residents and their families were 317 people and 129 people. In this follow-up, 55 (29.9%) and 20 (14.8%) of the first antibody-positive residents and patient family members were still positive; the first negative residents and their families were 47 (14.8%). ) and 11 people (8.52) became positive. A total of 11 cases were followed up for 3 years. Among them, 3 were BT and 8 were BL8. Eight cases of BL were positive for antibodies at the time of onset. Among them, 7 cases were also positive for the first antibody test, and 6 cases had a gradually increasing titer. The average time for positive segmentation was 26 months; 1 case of 3 cases of BT was positive for the first antibody. . However, they were negative at the time of onset. The authors believe that in villages with a high incidence of disease, serological screening and screening of patients with high-titer antibodies may be performed. Blood follow-up of patients with positive primary antibodies at intervals of 2 years may be helpful in detecting multiple bacteria. Type of patient but may not be appropriate at the site as a routine.