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由于青霉素的出现改变了感染性心内膜炎的预后。感染性心内膜炎的治疗,至今还在不断发展。特别是最近,对感染的瓣膜已经进行积极的外科手术。东京大学第2内科统计入院病例的死亡率,1947年以前是100%,开始使用青霉素的1948年是44.8%,1951～1963年是27.9%,1964～1978年为13.0%或更低。另外,美国30年来所发生的感染性心内膜炎,不仅仅是预后方面,而且病情也发生了明显的变化:(1)生存率上升,(2)有高龄倾向,(3)病原菌中的绿色链球菌、肺炎双球菌,淋球菌减少,而葡萄球菌和真菌的比率增加,(4)作为基础疾病的风湿性瓣膜病减少,同时
As the emergence of penicillin has changed the prognosis of infective endocarditis. Infective endocarditis treatment, is still under continuous development. In particular recently, aggressive surgery has been performed on infected valves. The mortality rate for the second medical statistics at the University of Tokyo was 100% before 1947, 44.8% in 1948 when penicillin was first used, 27.9% in 1951-1963, and 13.0% in 1964-1978. In addition, the United States 30 years of infective endocarditis occurred, not just the prognosis, but also the disease has undergone significant changes: (1) increased survival, (2) the tendency of aging, (3) pathogens Streptococcus pneumoniae, Streptococcus pneumoniae, Neisseria gonorrhoeae decreased, while staphylococci and fungi increased, (4) reduced rheumatic valvular disease as a primary disease, while