论文部分内容阅读
目的探讨氯沙坦联合氨氯地平治疗社区高血压合并糖尿病患者的临床疗效。方法选取2013年5月至2015年5月东莞市企石镇社区卫生服务中心收治的原发性高血压合并糖尿病患者90例为研究对象,按随机数字表法分为观察组和对照组,每组45例。观察组患者给予氯沙坦联合苯磺酸氨氯地平治疗,对照组患者给予苯磺酸氨氯地平治疗,比较两组患者的收缩压(SBP)、舒张压(DBP)、空腹胰岛素(FINS)、空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、血肌酐(SCr)、血尿酸(UA)、血尿素氮(BUN)、血钾(K)及尿微量蛋白(Alb)等,以及两组临床疗效、不良反应发生率。结果观察组患者治疗后SBP为(136±10)mm Hg、DBP为(81±3)mm Hg,均低于对照组,差异均有统计学意义(均P<0.05)。观察组患者治疗后FBG、FINS、Hb A1c、UA、SCr及Alb均显著低于对照组,差异均有统计学意义(均P<0.05)。观察组患者的有效率为95.6%,高于对照组的71.1%,差异有统计学意义(P<0.05)。两组患者的不良反应发生率差异无统计学意义(P>0.05)。结论氯沙坦联合氨氯地平治疗社区高血压合并糖尿病疗效显著,优于单一使用氨氯地平治疗,可有效降低患者的血压,控制血糖,且具有很好的肾脏保护作用,且不增加不良反应,安全可靠。
Objective To investigate the clinical efficacy of losartan combined with amlodipine in the treatment of community-based hypertensive patients with diabetes mellitus. Methods Ninety patients with essential hypertension complicated with diabetes mellitus admitted to Qishi Town Community Health Service Center of Dongguan City from May 2013 to May 2015 were divided into observation group and control group according to random number table Group of 45 cases. Patients in the observation group were treated with losartan and amlodipine besylate, and patients in the control group were treated with amlodipine besylate. SBP, DBP, FINS, FBG, SCr, UA, BUN, K and ALB, etc, as well as two groups Clinical efficacy, the incidence of adverse reactions. Results The SBP in the observation group was (136 ± 10) mm Hg and (81 ± 3) mm Hg after treatment, both of which were significantly lower than those of the control group (all P <0.05). The FBG, FINS, Hb A1c, UA, SCr and Alb in observation group were significantly lower than those in control group after treatment (all P <0.05). The effective rate of the observation group was 95.6%, higher than 71.1% of the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Losartan combined with amlodipine in the treatment of community-based hypertension and diabetes mellitus is significantly better than the single treatment with amlodipine, which can effectively reduce the patient’s blood pressure, control blood sugar, and has good renal protection, and does not increase adverse reactions ,Safe and reliable.