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目的观察纳络酮早期治疗慢性呼吸衰竭并肺性脑病的临床效果,探讨慢性呼吸衰竭并肺性脑病早期治疗药物。方法选择78例早期慢性呼吸衰竭并肺性脑病患者,随机分为观察组和对照组,两组均给予治疗原发病、吸氧、应用抗生素、纠正酸碱平衡及电解质紊乱等常规治疗。观察组在常规治疗的基础上,加服纳络酮治疗。结果观察组有效率84.6%,对照组有效率61.5%,观察组有效率明显好于对照组,两组相比有统计学意义(P<0.05)。结论盐酸纳络酮能促进肺性脑病患者神志、意识障碍的恢复,改善通气,增加PaO2,降低PaCO2,疗效满意。
Objective To observe the clinical effect of naloxone on early treatment of chronic respiratory failure and pulmonary encephalopathy and to explore the early treatment of chronic respiratory failure and pulmonary encephalopathy. Methods Seventy-eight patients with chronic respiratory failure and pulmonary encephalopathy were randomly divided into observation group and control group. Both groups were given routine treatment of primary disease, oxygen inhalation, antibiotics, acid-base balance and electrolyte imbalance. The observation group was treated with naloxone on the basis of routine treatment. Results The effective rate was 84.6% in the observation group and 61.5% in the control group, and the effective rate in the observation group was significantly better than that in the control group (P <0.05). Conclusion Naloxone hydrochloride can promote the recovery of consciousness and disturbance of consciousness in patients with pulmonary encephalopathy, improve ventilation, increase PaO2 and decrease PaCO2, and the curative effect is satisfactory.