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目的:探讨慢性前列腺炎(CP)的细菌学病因。方法:前列腺标本取自140例意外死于非前列腺疾病的器官捐献者,年龄20～35岁。取前列腺周围带组织,分成两块,一块做常规病理检查和抗IgA抗体组化染色,另一块用PCR方法检测细菌16SrRNA基因(16SrDNA)。结果:32.9%(46/140)的组织病理呈CP,其中轻度灶性间质炎42例,轻度灶性间质伴腺体周围炎3例,轻度灶性腺体周围炎1例。16SrDNA阳性率为19.3%(27/140)。其中前列腺炎标本阳性率为48.9%(22/46),非前列腺炎标本阳性率为5.3%(5/94),前列腺炎标本阳性率高于非前列腺炎标本(x2=36.910,P<0.01)。在CP标本中,16SrDNA阳性组IgA表达高于16SrDNA阴性组(Z=-3.85,P<0.001)。结论:细菌感染可能是引起CP的重要原因。
Objective: To investigate the bacteriological etiology of chronic prostatitis (CP). METHODS: Prostate specimens were obtained from 140 organ donors who died of unexpected prostate disease, aged 20-35 years. Take the surrounding prostate tissue, divided into two, one for routine pathological examination and anti-IgA antibody staining, the other with the PCR method for bacterial 16SrRNA gene (16SrDNA). Results: The histopathology of 32.9% (46/140) showed CP, including 42 cases of mild focal interstitial inflammation, 3 cases of mild focal interstitial glandular inflammation and 1 case of mild focal glandular inflammation . The positive rate of 16SrDNA was 19.3% (27/140). The positive rate of prostatitis specimens was 48.9% (22/46), that of non-prostatitis specimens was 5.3% (5/94), and the positive rate of prostatitis specimens was higher than that of non-prostatitis specimens (x2 = 36.910, P <0.01) . In CP samples, IgA expression in 16SrDNA positive group was higher than that in 16SrDNA negative group (Z = -3.85, P <0.001). Conclusion: Bacterial infection may be an important cause of CP.