阿斯匹林是一古老的解热镇痛抗风湿药。自Dreser(1899)推出阿斯匹林用于临床,已有近100年的历史。在本世纪70年代初,Ferreira和Smith等相继证实了阿斯匹林具有抑制体内多种组织中前列腺素生物合成的作用。Roth等进一步研究证明阿斯匹林能使前列腺素合成酶系中环氧化酶活性中心的丝氨酸氨基末端乙酰化而失活。这些新的发现引起了人们极大的兴趣,并对此进行了深入广泛的研究。从药代动力学角度来看, Aspirin is an ancient antipyretic analgesic antirheumatic drug. Since Dreser (1899) introduced aspirin for clinical use, it has been nearly 100 years old. In the early 70s of this century, Ferreira and Smith have confirmed that aspirin has the effect of inhibiting prostaglandin biosynthesis in various tissues in vivo. Further studies by Roth et al. Demonstrated that aspirin can acetylate serine amino terminus of the cyclooxygenase activity center in the prostaglandin synthase system and inactivate it. These new findings aroused great interest and conducted extensive and extensive research. From the pharmacokinetic point of view,