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目的 :观察铋制剂、洛赛克、替硝唑治疗幽门螺杆菌 (Hp)阳性消化性溃疡的近期和远期疗效。方法 :将10 2例患者随机分为两组 ,治疗组 (5 2例 ) :丽珠得乐冲剂 1.0 g,1d4次 ;洛赛克 2 0 mg,替硝唑 0 .5 g,1d2次口服 ;疗程 2周。对照组 (5 0例 ) :洛赛克 2 0 mg,qd头孢羟氨苄 0 .5 g,1d4次 ;甲硝唑 40 0 mg,1d2次 ;疗程 2周。疗程结束后 2周行胃镜检查 ,病理检查及 Hp检测 ;并于半年 ,1年进行相应的随访 ,结果 :治疗组和对照组溃疡愈合率分别为 90 .38%和 88.0 0 % ,Hp根除率分别为 88.46 %和 86 .0 0 % ,两组比较无显著差异 (P >0 .0 5 )。治疗组疗程后半年、1年溃疡复发率为 2 .17%和 4.35 % ,Hp再发率为 4.35 %和 6 .5 2 % ;对照组疗程后半年、1年溃疡复发率为14.2 9%和 19.0 5 % ,Hp再发率为 19.0 5 %和 2 1.43%。两组比较有显著差异 (P <0 .0 5 )。铋制剂、洛赛克加替硝唑治疗 Hp阳性溃疡的远期疗效优于洛赛克加两种抗生素的疗效 ,差异显著 (P <0 .0 5 )。结论 :两种疗法近期疗效相似 ,但远期疗效治疗组优于对照组 (P >0 .0 5 )
Objective: To observe the short-term and long-term efficacy of bismuth preparation, Losec and tinidazole in the treatment of Helicobacter pylori (Hp) -positive peptic ulcer. Methods: 102 patients were randomly divided into two groups: treatment group (52 cases): Lizhu Dele Granules 1.0 g, 1d4 times; Losec 20 mg, tinidazole 0.5 g, 1d2 times orally ; Treatment for 2 weeks. The control group (50 cases): Losec 20 mg, qd cefadroxil 0 .5 g, 1d4 times; metronidazole 40 0 mg, 1d2 times; course of treatment for 2 weeks. Two weeks after the end of treatment, gastroscopy, pathological examination and Hp detection were performed. Follow-up was performed at six months and one year. Results: The healing rates of the ulcer in the treatment group and the control group were 90.38% and 88.0%, respectively. Hp eradication rate Respectively 88.46% and 86.0%, there was no significant difference between the two groups (P> 0.05). One-year ulcer recurrence rates were 2.17% and 4.35% in one-year treatment and 4.35% and 6.52% respectively in the treatment group. The ulcer recurrence rate in the control group was 14.29% and 19.0 5%, Hp recurrence rate of 19.0 5% and 2 1.43%. There was significant difference between the two groups (P <0.05). The long-term curative effect of bismuth preparation and Losec plus tinidazole in the treatment of Hp-positive ulcers is superior to that of Losec plus two antibiotics (P <0.05). Conclusion: The short-term curative effects of the two therapies are similar, but the long-term curative effect is better than the control group (P> 0.05)